CXCL12 and CXCR4 in bone marrow physiology
Copyright policy )CXCL12 and CXCR4 in bone marrow physiology
This article discusses the multiple roles of CXCL12 and its receptor, CXCR4, in bone marrow (BM) hematopoietic stem cell (HSC) development and regulation. CXCL12 interaction with CXCR4 results in effects as varied as cell migration, proliferation and survival or apoptosis. The selective signaling pathways that mediate these varied outcomes are summarized briefly. The CXCL12/CXCR4 pair is crucially involved in homing and repopulation of HSCs in the specific BM niches. Mechanisms of HSC mobilization to the peripheral circulation in response to physiological requests and therapeutic stimulations, as well as recent data on the novel receptor for CXCL12, CXCR7, are reviewed.
- French Institute of Health and Medical Research France
- Cleveland Clinic Lerner Research Institute United States
- Cleveland Clinic United States
Receptors, CXCR, Receptors, CXCR4, Hematopoietic Stem Cell Transplantation, Intracellular Signaling Peptides and Proteins, Hematopoietic Stem Cells, Chemokine CXCL12, Hematopoietic Stem Cell Mobilization, Mice, Bone Marrow, Cell Movement, Animals, Humans, Signal Transduction
Receptors, CXCR, Receptors, CXCR4, Hematopoietic Stem Cell Transplantation, Intracellular Signaling Peptides and Proteins, Hematopoietic Stem Cells, Chemokine CXCL12, Hematopoietic Stem Cell Mobilization, Mice, Bone Marrow, Cell Movement, Animals, Humans, Signal Transduction
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