Superficial skin infections caused by Staphylococcus aureus and Streptococcus pyogenes include primary infections, such as impetigo, and secondary infections, such as secondarily infected dermatitis or traumatic lesions. Such infections are some of the most common indications for antimicrobial therapy, with the particular choice of therapy depending on the type and extent of disease, as well as the likely pathogen, local antibiotic susceptibility profile and patient factors, such as age or potential for the development of adverse effects. We provide an overview of uncomplicated skin and skin structure infections and their causative pathogens, and review current treatment options for managing these infections and for preventing further complications. In addition, we introduce some emerging treatment measures, which may combat the rise in antibiotic resistance.