Objetive: This study is aimed to determine the working conditions, health and quality of life of workers involved in the driving industry. Materials and Methods: An integrative review was carried out in the Medline/PubMed, VHL, Web of Science, and Scopus databases, referring to articles related to working conditions, health, and quality of life of workers in the driving industry which had been published between 2010 and 2019, following the guidelines set forth by Ganong. Results: 29 studies met the selected criteria, which were conducted in the driver population working in the area of means of transport such as buses, taxis, motorcycles and the area of cargo transport such as trucks. Discussion: The reality experimented by these workers creates awareness and opens up a space to implement healthcare policies that seek their wellbeing, and at the same time, it is a gateway to creating knowledge about the need to study this population group. Conclusions: The quality of life and working conditions of these drivers are mostly inadequate, affecting them negatively in different ways. Moreover, the health of this group of workers is getting affected by the working conditions that many of them may have, and most of them lack good health practices, having unhealthy habits that are directly related to the work they do. How to cite this article: Sepúlveda Guerra Elena Belén, Valenzuela Suazo Sandra Verónica, Rodríguez Campo Varinia Alejandra. Condiciones laborales, salud y calidad de vida en conductores. Revista Cuidarte. 2020; 11(2): e1083. http://dx.doi.org/10.15649/cuidarte.1083