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Sovremennaâ Pediatriâ
Article . 2019 . Peer-reviewed
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Human Virome

Виром человека
Authors: D.S. Yankovsky; G.S. Dyment; V.V. Berezhniy; V.O. Kitam; N.V. Khimich;
Abstract

The review is dealt with virome, a viral component of human microbiome. Modern data are discussed that concern the structure of virome, its formation during ontogenesis, the role in disease pathogeneses and in homeostasis maintenance. Special attention is payed to bacteriophages (phagobiome) as dominant members of virome. Modern data are submitted about the influence of bacteriophages on the state of microbiome prokaryotic community, immune system and their potential participation in the development of pathologies. Controversial questions, connected with the perspective of using bacteriophage therapy in medicine, are considered.

Обзор посвящен изучению вирусного компонента микробиома человека — вирома. Приведены современные данные, касающиеся состава вирома, его формирования в процессе онтогенеза, роли в патогенезе болезней или поддержании гомеостаза. Особое внимание уделено бактериофагам (фагобиому) как доминантному члену вирома. Представлены сведения о влиянии бактериофагов на состояние прокариотного сообщества микробиома, иммунную систему и их потенциальное участие в развитии патологии. Рассмотрены дискуссионные вопросы, касающиеся перспектив использования бактериофаговой терапии в медицине.

Огляд присвячений вивченню вірусного компонента мікробіому людини — вірому. Наведені сучасні дані щодо складу вірому, його формування у процесі онтогенезу, ролі в патогенезі хвороб або підтримці гомеостазу. Особлива увага приділена бактеріофагам (фагобіому) як домінантному члену вірому. Наведені відомості про вплив бактеріофагів на стан прокаріотного співтовариства мікробіому, імунну систему та їх потенційну участь у розвитку патології. Розглянуті дискусійні питання, що стосуються перспектив використання бактеріофагової терапії у медицині.

Keywords

фаговая терапия, bacteriophages, phage therapy, вирусы, бактеріофаги, виром, microbiome, фагова терапія, prokaryotes, фагобіом, бактериофаги, viruses, метагеноміка, virome, metagenomics, прокаріоти, прокариоты, віруси, віром, микробиом, phagobiome, фагобиом, мікробіом, метагеномика

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
1
Average
Average
Average
gold