AbstractDevices for tissue engineering comprise scaffolds with the appropriate chemistry and architecture to promote cell infiltration and colonization. The scaffold is designed with biology in mind, and thus the architecture and chemistry differ according to tissue type. In this review, we focus on scaffolds for two tissue types—bone and nervous tissue—and describe different approaches used to create them. The appropriate scaffold for a hard tissue such as bone has a high degree of interconnected macroporosity and allows the rapid invasion of cells while maintaining a rigid structure. Several approaches are described for constructing tissue-engineering scaffolds for bone. The appropriate scaffold for soft tissues like nerve fibers (e.g., axons, which conduct nerve impulses) also has a high degree of interconnected pores; however, the pores may require orientation and may be smaller. Homogeneous, high-water-content hydrogels with mechanical properties that match the soft nerve tissue are commonly used as a scaffold, and the methods used to make these are reviewed.