Ultra-high-performance concrete (UHPC) is a high-strength, high-durability composite material consisting of a cementitious matrix with high-performance-fiber reinforcement. This publication provides a practical guide for the development and qualification of UHPC mixtures based on locally available materials. It presents an overview of UHPC production specific to long-span precast, pretensioned UHPC structural elements for buildings and bridges. Many of the practices discussed apply to the production of a variety of UHPC elements. Topics discussed include the constituent materials and development of mixture proportions, batching and placement considerations for production, and methods for evaluating UHPC materials for mixture qualification and routine quality assurance.