In modern conditions the processes of functioning and developing of economic systems at any level: national, regional or at a level of the main link of the economy depend on various factors such as the environment. The environment quality plays an increasingly important role as a factor for stable development of the society and ensures the competitiveness of Ukraine’s economy on the world market. Significant ecological diversification of the Ukraine’s territory and peculiarity of the social and economic processes in the regions, which in the historical, natural, social, economic relations are far from dissimilar, actualize the problem of regionally differentiated approaches to the management of ecological safety. In the same time, the low effectiveness of the state management mechanisms of sustainable environmental development of Ukraine causes the objective necessity to ensure the ecological and economic security of the country and its regions. That requires a corresponding theoretical basis, methodological approaches, scientific substantiation of directions and its implementation. It is really important to investigate the environmental management mechanisms in the region on the basis of three main activities directed on implementing the ecological safety concept — informational, administrative and economic. The management mechanisms of ecological security in the region were analyzed in the paper. The information, administrative and economic activities directed on implementing the environmental safety concept were considered. The solution of environmental safety problems of economic systems (national, regional, local levels) requires the introduction of a mechanism for environmental management. The formation of regional and national systems of ecological safety will ensure the correspondence of environmental management mechanisms with liabilities of Ukraine on multilateral environmental agreements. These agreements are an important tool for ensuring sustainable development of the state and support to the European system of ecological safety.