In this article we prove sharp Landau-Kolmogorov type inequalities on a class of charges defined on Lebesgue measurable subsets of a cone in $\mathbb{R}^d$, $d\geqslant 1$, that are absolutely continuous with respect to the Lebesgue measure. In addition we solve the Stechkin problem of approximation of the Radon-Nikodym derivative of such charges by bounded operators and two related problems. As an application, we also solve these extremal problems on classes of essentially bounded functions $f$ such that their distributional partial derivative $\frac{\partial ^d f}{\partial x_1\ldots\partial x_d}$ belongs to the Sobolev space $W^{1,\infty}$.