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Genetics
Article . 2008 . Peer-reviewed
License: OUP Standard Publication Reuse
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Genetics
Article
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https://dx.doi.org/10.48550/ar...
Article . 2007
License: arXiv Non-Exclusive Distribution
Data sources: Datacite
Genetics
Article . 2008
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An Accurate Model for Genetic Hitchhiking

Authors: Pontus Fernström; Anders Eriksson; Serik Sagitov; Bernhard Mehlig;

An Accurate Model for Genetic Hitchhiking

Abstract

AbstractWe suggest a simple deterministic approximation for the growth of the favored-allele frequency during a selective sweep. Using this approximation we introduce an accurate model for genetic hitchhiking. Only when Ns < 10 (N is the population size and s denotes the selection coefficient) are discrepancies between our approximation and direct numerical simulations of a Moran model notable. Our model describes the gene genealogies of a contiguous segment of neutral loci close to the selected one, and it does not assume that the selective sweep happens instantaneously. This enables us to compute SNP distributions on the neutral segment without bias.

Keywords

Gene Frequency, Models, Genetic, FOS: Biological sciences, Populations and Evolution (q-bio.PE), Humans, Selection, Genetic, Quantitative Biology - Populations and Evolution, Alleles, Genealogy and Heraldry

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
12
Average
Average
Top 10%
Green
hybrid
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