Regulation of the neuroendocrine reproductive axis by kisspeptin-GPR54 signaling
Copyright policy )Regulation of the neuroendocrine reproductive axis by kisspeptin-GPR54 signaling
Abstract The Kiss1 gene codes for a family of peptides that act as endogenous ligands for the G protein-coupled receptor GPR54. Spontaneous mutations or targeted deletions of GPR54 in man and mice produce hypogonadotropic hypogonadism and infertility. Centrally administered kisspeptins stimulate gonadotropin secretion by acting directly on GnRH neurons. Sex steroids regulate the expression of KiSS-1 mRNA in the brain through direct action on KiSS-1 neurons. In the arcuate nucleus (Arc), sex steroids inhibit the expression of KiSS-1, suggesting that these neurons serve as a conduit for the negative feedback regulation of gonadotropin secretion. In the anteroventral periventricular nucleus (AVPV), sex steroids induce the expression of KiSS-1, implying that KiSS-1 neurons in this region may have a role in the preovulatory LH surge (in the female) or sexual behavior (in the male).
- University of Mary United States
- University of Washington United States
Male, Neurons, Kisspeptins, Reproduction, Tumor Suppressor Proteins, Brain, Receptors, G-Protein-Coupled, Gonadotropin-Releasing Hormone, Mice, Pituitary Gland, Gonadotropins, Pituitary, Animals, Humans, Female, Gonadal Steroid Hormones, Receptors, LHRH, Receptors, Kisspeptin-1, Signal Transduction
Male, Neurons, Kisspeptins, Reproduction, Tumor Suppressor Proteins, Brain, Receptors, G-Protein-Coupled, Gonadotropin-Releasing Hormone, Mice, Pituitary Gland, Gonadotropins, Pituitary, Animals, Humans, Female, Gonadal Steroid Hormones, Receptors, LHRH, Receptors, Kisspeptin-1, Signal Transduction
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).218 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 1%
Citations provided by BIP!Popularity provided by BIP!