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Article . 1993 . Peer-reviewed
License: OUP Standard Publication Reuse
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J Reprod Fertil
Article . 1993
Data sources: Europe PubMed Central
https://dx.doi.org/10.1530/jrf...
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Natural killer cytotoxicity and antibody-dependent cytotoxicity of cells of rat metrial glands

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 1993 English Publisher:Oxford University Press (OUP)Journal:Reproduction, volume 98, pages 489-494 (issn: 1470-1626, eissn: 1741-7899, Copyright policy )
Authors: I J, Stewart; S, Peel;

doi: 10.1530/jrf.0.0980489

pmid: 8410815

Natural killer cytotoxicity and antibody-dependent cytotoxicity of cells of rat metrial glands

Abstract

Cell suspensions of rat metrial gland tissue, containing healthy granulated metrial gland (GMG) cells, were assessed for their ability to lyse natural killer (NK) cell target Yac-1 myeloma cells in a [51Cr]-release cytotoxicity assay. Cytotoxicity indices were found to be low even after in vivo stimulation of NK cytoxic activity by polyinosilic–cytidilic acid and the addition of interferon to test cultures. It is concluded that cell suspensions of rat metrial gland, and rat GMG cells in particular, do not exhibit NK cytotoxicity. However, when a heat inactivated rabbit anti-Yac-1 serum was added to assay cultures, cytotoxicity indices above background levels were obtained, indicating that rat metrial glands contain cells capable of antibody-dependent cytotoxicity.

Related Organizations
Keywords

Immune Sera, Antibody-Dependent Cell Cytotoxicity, Metrial Gland, Cytotoxicity Tests, Immunologic, Rats, Killer Cells, Natural, Pregnancy, Animals, Female, Rats, Wistar, Multiple Myeloma, Spleen

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    selected citations
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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 16
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
16
Average
Top 10%
Top 10%
bronze