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Reproduction
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Article . 1983 . Peer-reviewed
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J Reprod Fertil
Article . 1983
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Effects of LH-RH agonist or LH-RH immunoneutralization on pituitary and ovarian LH-RH receptors in female rats

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 1983 English Publisher:BioscientificaJournal:Reproduction, volume 69, pages 245-252 (issn: 1470-1626, eissn: 1741-7899, Copyright policy )
Authors: Hamish M. Fraser; Rachel M. Popkin; R. G. Gosden;

doi: 10.1530/jrf.0.0690245

pmid: 6310107

Effects of LH-RH agonist or LH-RH immunoneutralization on pituitary and ovarian LH-RH receptors in female rats

Abstract

Hyperstimulation of pituitary function using daily injections of 50,500 or 5000 ng LH-RH agonist for 3 weeks or hypostimulation by immunoneutralization of endogenous LH-RH led to disrupted oestrous cycles and profound changes in ovarian morphology. Despite this, the number of pituitary and ovarian LH-RH receptors remained within the range found in normally cyclic animals. Autoradiography confirmed that specific binding was located in theca, granulosa and luteal cells. These results suggest that autoregulation of pituitary and ovarian LH-RH receptors is not of primary importance in the cyclic female rat.

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Keywords

Ovary, Rats, Inbred Strains, Receptors, Cell Surface, Buserelin, Rats, Gonadotropin-Releasing Hormone, Estrus, Pregnancy, Pituitary Gland, Animals, Autoradiography, Female, Receptors, LHRH

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    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 19
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Average
    influence
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
19
Average
Top 10%
Top 10%
bronze
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