OPHTHALMOPATHY ASSOCIATED WITH PRIMARY HYPOTHYROIDISM

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 1975Publisher:Oxford University Press (OUP)Journal:Acta Endocrinologica, volume 79, pages 691-699 (issn: 0804-4643, eissn: 1479-683X,

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Authors: B E, Brownlie; O A, Newton; S P, Singh;

doi: 10.1530/acta.0.0790691

pmid: 1173968

OPHTHALMOPATHY ASSOCIATED WITH PRIMARY HYPOTHYROIDISM

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Abstract

ABSTRACT Ten patients with primary hypothyroidism and ophthalmopathy are reported. None of the patients had previously received any form of therapy for thyrotoxicosis. In some patients hypothyroidism and exophthalmos presented simultaneously, but in others one clinical feature preceded the other by many years. Elevated titres of thyroid antibodies were found in 7 of the 10 patients and LATS was detected in 1 of the 10 patients. Increased 35S-sulphate uptake by the mouse Harderian gland technique occurred with serum from I of the 7 patients tested.

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Keywords

Adult, Male, Ophthalmoplegia, Eye Diseases, Harderian Gland, Middle Aged, Thyroid Function Tests, Thyroglobulin, Antibodies, Graves Disease, Mice, Hypothyroidism, Eyelid Diseases, Animals, Humans, Long-Acting Thyroid Stimulator, Female, Aged

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