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The EMBO Journal
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Getting stress out of stressed‐out stress granules

descriptionPublicationkeyboard_double_arrow_right Article 23 May 2017 English Publisher:Springer Science and Business Media LLCJournal:The EMBO Journal, volume 36, pages 1,647-1,649 (issn: 0261-4189, eissn: 1460-2075, Copyright policy )
Authors: Pratibha Siwach; Daniel Kaganovich;

doi: 10.15252/embj.201797176

pmid: 28536150

pmc: PMC5470038

Getting stress out of stressed‐out stress granules

Abstract

Amyotrophic lateral sclerosis (ALS) pathology is linked to the aberrant aggregation of specific proteins, including TDP‐43, FUS, and SOD1, but it is not clear why these aggregation events cause ALS. In this issue of The EMBO Journal , Mateju et al (2017) report a direct link between misfolded proteins accumulating in stress granules and the phase transition of these stress granules from liquid to solid. This discovery provides a model connecting protein aggregation to stress granule dysfunction.

Related Organizations
Keywords

Stress, Physiological, 610, Humans, RNA, Messenger, Cytoplasmic Granules

  • BIP!
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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 9
    popularity
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    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
9
Top 10%
Average
Average
gold