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Inflammasomes and Atherosclerosis

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Jan 2016 English Publisher:Compuscript, Ltd.Journal:Cardiovascular Innovations and Applications, volume 1 (issn: 2009-8618, eissn: 2009-8782,

Authors: Yao Dai; J. L. Mehta; S. Vallurupalli;

doi: 10.15212/cvia.2016.0028

Inflammasomes and Atherosclerosis

- Summary
- Subjects
- Metrics

Abstract

Inflammation plays an important role in atherosclerosis. Inflammasomes play a crucial role in innate immunity, which mediates the body’s response to various pathogens. Of the different types of inflammasomes, NLRP3 has been implicated in atherosclerosis through the production of proinflammatory cytokines, IL-1β and IL-18. This review describes the role of the NLRP3 inflammasome in atherosclerosis and discusses potential therapeutic targets in the inflammasome pathway.

Related Organizations

Central Arkansas Veterans Healthcare System
United States
University of Arkansas for Medical Sciences
United States

Keywords

RC666-701, Diseases of the circulatory (Cardiovascular) system

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	1
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average