A fixed dose combination of ibuprofen and famotidine

descriptionPublicationkeyboard_double_arrow_right Article 06 Aug 2009 English Publisher:Informa UK LimitedJournal:Expert Opinion on Investigational Drugs, volume 18, pages 1,385-1,391 (issn: 1354-3784, eissn: 1744-7658,

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Authors: John W, Birk; Matthew, Myers;

doi: 10.1517/13543780903160641

pmid: 19659445

A fixed dose combination of ibuprofen and famotidine

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Abstract

The NSAID class of medications is frequently used for mild to moderate pain. While overall safe, NSAIDs have several important adverse effects including esophageal, gastric and duodenal ulceration which limit their use. This has led to the development of NSAIDs with either less gastrointestinal side effects or concurrent use of medications to prevent NSAID gastrointestinal side effects. While several classes of medications exist for the prevention of gastrointestinal side effects, few combination treatments are available in a single pill. Towards this end, a combination pill of ibuprofen and famotidine (HZT-501, Horizon Therapeutics, Skokie, IL. USA) has been developed.

Related Organizations

University of Connecticut Health Center
United States

Keywords

Drug Combinations, Clinical Trials, Phase III as Topic, Gastrointestinal Diseases, Anti-Inflammatory Agents, Non-Steroidal, Humans, Pain, Ibuprofen, Anti-Ulcer Agents, Famotidine

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