descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 2008 English Publisher:Walter de Gruyter GmbHJournal:Zeitschrift für Naturforschung C, volume 63, pages 21-28 (issn: 0939-5075, eissn: 1865-7125,

Authors: Elza de Fátima Albino Smânia; Artur Smânia; Cláudia Groposoa; Franco Delle Monache; Simone Machado de Souza; Cristina Montagner;

doi: 10.1515/znc-2008-1-205

pmid: 18386483

Antifungal Activity of Coumarins

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Abstract

The antifungal activity of 40 coumarins was tested against the fungal strains: Candida albicans (ATCC 14053), Aspergillus fumigatus (ATCC 16913) and Fusarium solani (ATCC 36031), using the broth microdilution method. Osthenol showed the most effective antifungal activity among all the compounds tested, with a MIC value of 125 μg/ml for Fusarium solani and 250 μg/ml for Candida albicans and Aspergillus fumigatus. The antifungal potential of this prenylated coumarin can be related to the presence of an alkyl group at C-8 position.

Related Organizations

Universidade Federal de Santa Catarina
Brazil
Catholic University of the Sacred Heart
Italy

Keywords

Models, Molecular, Structure-Activity Relationship, Antifungal Agents, Fusarium, Coumarins, Aspergillus fumigatus, Candida albicans, Microbial Sensitivity Tests

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