<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=undefined&type=result"></script>');
-->
</script>

COPY SCRIPT

For further information contact us at helpdesk@openaire.eu

Affinity of tocolytic agents on human placental and myometrial beta-adrenergic receptors

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1986 Hungary, Germany English Publisher:Walter de Gruyter GmbHJournal:Journal of Perinatal Medicine, volume 14, pages 109-113 (issn: 0300-5577, eissn: 1619-3997,

Authors: Falkay, George; Kovács, László;

doi: 10.1515/jpme.1986.14.2.109

pmid: 2874205

Affinity of tocolytic agents on human placental and myometrial beta-adrenergic receptors

- Summary
- Subjects
- Metrics

Abstract

The beta-adrenoreceptor antagonist [3H]-dihydroalprenolol (DHA) has been used to label adrenoreceptors in membranes from human pregnant myometrium and placenta. Six tocolytic drugs were tested for their ability to bind to the beta-adrenergic receptor of placental and myometrial membranes. Tocolytic agents competed with [3H]-DHA binding in the following order of potency: clenbuterol greater than fenoterol greater than ritodrine greater than isoxsuprine greater than orciprenaline greater than terbutaline. All drugs competed for [3H]-DHA binding sites with HILL coefficients greater than unity indicating heterogeneity of binding. In general, binding of beta-adrenoreceptor agonists was weaker in myometrium than in placenta homogenates. According to our results it is very likely that the placenta may play an important role in the pharmacological mechanism of tocolytic agents in inhibitory of premature labor.

Countries

Hungary, Germany

Related Organizations

University of Szeged
Hungary
Humboldt-Universität zu Berlin
Germany

Keywords

Placenta, Adrenergic beta-Agonists, In Vitro Techniques, Binding, Competitive, Obstetric Labor, Premature, Pregnancy, Receptors, Adrenergic, beta, Dihydroalprenolol, Myometrium, Humans, Female, 03.02. Klinikai orvostan

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	7
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average