CYP2C8 polymorphism among the Portuguese

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 2006Publisher:Walter de Gruyter GmbHJournal:Clinical Chemistry and Laboratory Medicine (CCLM), volume 44 (issn: 1434-6621, eissn: 1437-4331,

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Authors: Isa, Cavaco; Rita, Piedade; J Pedro, Gil; Vera, Ribeiro;

doi: 10.1515/cclm.2006.030

pmid: 16475901

CYP2C8 polymorphism among the Portuguese

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Abstract

AbstractCytochrome P450 2C8 (CYP2C8) is a polymorphic phase I drug-metabolising enzyme involved in the metabolism of a wide variety of xenobiotics, as well as a proposed player in the regulation of vascular tone. Polymorphisms in this gene may have an impact on the metabolism of therapeutic drugs such as paclitaxel and verapamil. In this report we have determined the frequencies of the main non-synonymous

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Keywords

Male, Polymorphism, Genetic, Portugal, White People, Cytochrome P-450 CYP2C8, Gene Frequency, Humans, Female, Aryl Hydrocarbon Hydroxylases, Alleles

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