Hypodontia or tooth agenesis is a condition at which the patient is missing one or more teeth due to a failure of those teeth to develop. This is not only an aesthetic, but also a functional deficiency. The incidence of congenitally missing teeth depends on etiological factors that affect tooth development, as well as which dentition is concerned, sex or race and geographic distribution. The tooth agenesis is mostly seen in teeth that are formed last in a given class (lateral incisors, second premolars and third molars). The aim of this study was to calculate the prevalence of congenitally missing teeth in population of FYROM and, through a review of the literature, to compare these results to other populations in the world. For this purpose a retrospective, transversal and cross-sectional study was made, where dental history and anamnesis of 8160 patients (3671 males and 4489 females) were examined, as well as their panoramic radiographs. The patients were 8-18 years old. The data was statistically analyzed with programme Statistica 7.0. The prevalence of hypodontia population of FYROM was 7.52%. Most commonly congenitally missing tooth in patients with hypodontia was mandibular second premolar (35.5% left and 34.53% right). Tooth agenesis predominated in females and in ethnic Albanian population, without significance.