State estimation techniques have been widely discussed in academia in the context of water distribution systems, but there are few real-life applications. The aim of this paper is to show the potential advantages of systematically implementing state estimation techniques for on-line monitoring water distribution systems. With this purpose, two state estimation-based methodologies are here applied to C-Town case study: (1) calibration via multi-period state estimation, in order to adjust model parameters based on state estimation results over time, and (2) topological state estimation, in order to identify changes in the statuses of pumps and valves. Results show that state estimation techniques are a good alternative to adapt the paradigm of water distribution networks analysis to the reality of telemetry systems.