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The metabolism of estriol-3-glucosiduronate and estriol in the rabbit.

descriptionPublicationkeyboard_double_arrow_right Article 01 Jan 1980 English Publisher:Japan Endocrine SocietyJournal:Endocrinologia Japonica, volume 27, pages 175-182 (issn: 0013-7219, eissn: 2185-6370,

Authors: Yoshitaka Araki; Naokata Shimizu; Hiroshi Mizukoshi; Tatsuo Miyazaki;

doi: 10.1507/endocrj1954.27.175

pmid: 6250804

The metabolism of estriol-3-glucosiduronate and estriol in the rabbit.

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Abstract

Urinary metabolites of [6,7-3H]-estriol-3-glucosiduronate and of [6, 7-3H]-estriol in intact female rabbits were analyzed. The separation of urinary metabolites was performed by countercurrent distribution followed by DEAE-Sephadex A-25 column chromatography. Each conjugate was then hydrolyzed with the enzymes and the aglycone thus liberated was identified. In either case, major urinary metabolites were found to be diconjugates, a considerable part of which was glucosiduronate-N-acetylglucosaminide of 17-epiestriol. In addition, estriol-16-glucosiduronate or monoglucosiduronate of 17-epiestriol was identified as a minor urinary metabolite of [6,7-3H]-estriol. From these results, it was concluded that the greater part of the estriol-3-glucosiduronate was converted to diconjugates and that estriol-3-glucosiduronate was probably an intermediate metabolite in the conversion pathway from estriol to diconjugates in this species.

Related Organizations

Teikyo University
Japan
University of Tokyo
Japan

Keywords

Estrogens, Conjugated (USP), Estriol, Hydrolysis, Animals, Female, Glucuronates, Rabbits, Chromatography, Ion Exchange

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