The numerical simulation of fluid-structure interaction requires a simulation tool that can calculate both fluid flow and structure deformation and takes into account the results of one code (i.e., forces and deformations) in the setup of the other (as motion and load). This article shows a segregated (also: partitioned) approach that uses commercial, highly developed software for each task: ANSYS CFX for fluid dynamics and ANSYS Mechanical for structural mechanics with the ANSYS MFX solver to couple both programs. Two examples with large deformations and strong influence on the flow field are shown: The Turek benchmark from Turek and Hron (2006) consists of a laminar incompressible channel flow around an elastic object which results in periodic oscillations of the structure. The second example is the discharge simulation of compressed air through a rapidly moving reed valve in a piston compressor where opening and closing contacts are important.