This paper explores new challenges and possible approaches for developing mobile information systems, with an emphasis on model-based approaches on the conceptual and logical levels. Over the last few years, we have experienced these new challenges through our involvement in several research and industrial projects on mobile solutions, usability and model-based approaches. We summarise the main challenges of how model-based approaches can support the development of mobile information systems that are to be used together with other types of systems in a primarily professional setting and indicate upcoming research issues in this very dynamic area.