The traditional view of Strategic Information Systems (SIS) study focuses on the linkage between information system strategies with its relevant strategies (e.g. business strategy, organisational strategy and IT objectives). This study extends this conventional notion by introducing a new perspective on SIS. Adopting McFarlan and McKenney's strategic grid framework, the purpose of this study is to empirically test the relationship between IS dependency and IS strategies using Structural Equation Modelling (SEM). We hypothesise that IS dependency practices will have a positive direct impact on IS strategies. The findings from this research will contribute to both practitioners who make information system decisions and IS researchers. The development of measurement, hypothesis and implications will be discussed.