Consanguineous marriages are characteristic features of particularly the traditional system. Furthermore they are significant fields of anthropology/ medical anthropology in terms of the fact that they set forth the analysis between culture and health. In this respect, consanguineous marriages and their auses are examined anthropologically in frontier villages of Akcakale and Reyhanli where these kinds of marriages are frequently observed. The sample of the study includes 153 families, 68 of which are from the four villages of Akcakale in Sanliurfa and 85 of which are from the four villages of Reyhanli in Hatay. While consanguineous marriages of the sample group Reyhanli district is 88.2 %, consanguinity rate of the sample group Akcakale district is 72 %. The main reason leading to this can be counted as a social-cultural factors (attributed to the role within the community, economic concerns…) and geographical factors. The frequency of space-borne disases owing to consangineous marriage in Akcakale research field is 27.9 % but this frequency is 41 % in Reyhanli research area.