The growth of urban areas and the impact of urban ecosystems on public health and urban sustainability are very important in big cities. The United Nations predicts that 60% of the world's population will live in cities by 2030. More than 10-15 million Turkish people suffer from pollen allergy and pollen allergy poses a major risk for humans. Pollen allergy induces bronchitis, bronchial asthma and may even be life-threatening. Thus, pollen allergies greatly affect the daily life of individuals. But nowadays, The allergenicity of plants, however, is often neglected. In this paper are suggested that the major causes of this extensive allergenicity, including: the presence of exotic and invasive species, the mutual effect between allergenic pollen and air pollutants, cross-reactivity between allergenic species and the choice of male plant which produce a lot of allergenic pollen individuals in dioecious species and the guidelines created by the study contain eight recommendations that, if implemented by city planners and local authorities, would reduce the effects of pollen on people living and working in cities