The aim of this chapter is to provide an overview of effective interventions aimed at the prevention of mental disorders and reduction of risk in early childhood, to promote child and adult well-being in scarce-resource contexts. The focus is on preschool children, that is, children under five years of age. Major risks to child mental health in this period are outlined and, as in the other chapters, examples of interventions at the individual, interpersonal, community and policy levels are presented.