Introduction: Esophageal malignancies are a diverse group of neoplastic processes. The different entries that contribute to the group have a very wide margin of incidence across different populations, attributed to the presence of different predisposing factors. The aim of this study was to establish the statistical prevalence of histologically verified esophageal neoplasms in a single medical institution. Materials and Methods: All histologically confirmed cases of malignancies isolated from the esophagus, for a period of three-and-a-half-years registered in the St. Marina University Hospital, Varna, Bulgaria, were retrieved from the pathological archive and their incidence compared in a descriptive statistical manner. The cases were further classified based on the age and gender of the patients. Results: For the set time period, 33 cases of esophageal malignancies were registered. From these cases 66.67% (n=22) were diagnosed as squamous cell carcinoma of the esophagus (SCCE), 30.30% (n=10) as adenocarcinoma of the esophagus (ACE) and 3.03% (n=1) as a non-Hodgkin’s B MALT lymphoma diagnoses in an 84-year-old male patient. The mean age of diagnosis of patients with SCCE (n=22) was 59.45 years of age, with a standard deviation of ±11.05 years, while the mean age of diagnosis of patients with ACE (n=10) was 70.40 years of age, with a standard deviation of ±14.83 years. Conclusion: The results show clear statistical difference in the mean age of diagnosis. The male-to-female ratio of all cases is comparable to that of the global population, while the statistical segregation between entries shows a tendency towards the developed countries.