Psoas syndrome is a rare form of muscle irritation that causes pain and weakness in the lower extremities. A 52-year-old male presented to the emergency department with complaints of having had a seizure and weakness in the left lower extremity. A computerized tomography scan of the abdomen and pelvis revealed reversible thickening of the left psoas muscle, consistent with psoas syndrome. We report a case of psoas syndrome following a generalized seizure and discuss its clinical characteristics and differential diagnoses.