When Is Suspected Drug-Induced Liver Injury (DILI) Not DILI? An Analysis of Unlikely Cases From the Drug-Induced Liver Injury Network

descriptionPublicationkeyboard_double_arrow_right Article 14 Jun 2023 English Publisher:Ovid Technologies (Wolters Kluwer Health)Journal:American Journal of Gastroenterology, volume 118, pages 2,301-2,304 (issn: 0002-9270, eissn: 1572-0241,

Authors: A Sidney, Barritt; Huiman, Barnhart; Jiezhun, Gu; Andrew, Dellinger; Sean, Rudnick; Herbert L, Bonkovsky;

doi: 10.14309/ajg.0000000000002370

pmid: 37311048

pmc: PMC10898250

When Is Suspected Drug-Induced Liver Injury (DILI) Not DILI? An Analysis of Unlikely Cases From the Drug-Induced Liver Injury Network

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Abstract

INTRODUCTION: Diagnosis of drug-induced liver injury (DILI) is difficult. We reviewed cases in the DILI Network prospective study that were adjudicated to have liver injury due to other causes to discover pearls for improved diagnostic accuracy. METHODS: Cases were adjudicated by expert opinion and scored from 1 (definite DILI) to 5 (unlikely DILI). Confirmed cases (1–3) were compared with unlikely cases (5). RESULTS: One hundred thirty-four of the 1,916 cases (7%) were unlikely DILI. Alternative diagnoses were autoimmune hepatitis (20%), hepatitis C (20%), bile duct pathology (13%), and hepatitis E (8%). DISCUSSION: Thorough evaluation, including follow-up, is essential to minimize incorrect diagnosis of idiosyncratic DILI.

Related Organizations

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Keywords

Causality, Liver, Humans, Prospective Studies, Chemical and Drug Induced Liver Injury, Hepatitis C

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