A recent study in the Journal of Frailty & Aging (1)investigated the stage-specific relationship between frailty andcognitive impairment among individuals attending a MemoryClinic. The Authors hypothesized that worsening of cognitivedecline may lead to increased frailty prevalence, beingcognition a well-established contributor to individualvulnerability and resiliency to stressors. Nevertheless,seemingly counter-intuitively, they observed a “U-shaped”relationship between frailty and cognitive impairment. Inparticular, the frailty prevalence was higher among individualsdiagnosed as mild cognitive impairment (MCI), was lower inmild Alzheimer’s disease (AD) patients, and again increased insubjects affected by moderate AD. The study, despite somemethodological issues potentially limiting the validity of results(i.e. the limited sample size), offers the opportunity to discussseveral important aspects.