One of the longest and most expensive parts of a standard tableting method is granulation. With the application of the direct compression tablet making, granulation can be omitted if the solid compound has proper compressibility and crystallographic properties. This is why the manufacturing of a spherical morphology is important. With the application of spherical particles the amount of the additives can be decreased, since they possess the optimal morphology themselves and this way the production of smaller tablets with the same dose of active pharmaceutical ingredient can be achieved. During the experimental section of the work, the methods for the preparation of spherical ambroxol hydrochloride (AMB HCl) were tested (both typical and non-typical methods) and the products were compared considering their mean particle size, morphology and surface smoothness values. The effective methods were chosen and were further optimized. The most promising spherical crystallization methods were the non-typical ones. In the first place, the spherical agglomeration (SA) method was optimized based on the Quality by Design (QbD) principals. It was started with a risk assessment. Firstly the critical parameters were determined and a factorial design was established with the given dependent and independent variables. During the statistical evaluation the significant effects and factors could be determined and so the optimal process parameters could be described. In the case of the non-typical crystallization methods, a real-time observation was also carried out by FBR-probe and the parameters of the slow cooling crystallization (ATP) were also optimized. Results of the product assay showed a high improvement in the powder rheology attributes, average particle size, aspect ratio and roundness values and as a final conclusion, it can be said that the above-mentioned methods with carefully described, optimized parameters are able to ease the tableting and the industrial processing of the crystalline AMB HCl.