Metastatic lesions of the jaws are relatively rare in relation to other pathological conditions of the oral and maxillofacial region. When present, they provide a diagnostic challenge and create a unique treatment role for the dental practitioner. The radiographic and clinical findings in patients with these lesions may mimic common inflammatory-infectious and posttraumatic conditions of the mouth and jaws. This review looks at the literature and clinical radiographic findings in patients with metastatic disease of the jaws. The role of the dental practitioner in the diagnostic and medical treatment phases is also discussed.