This article disputes claims of anti-fluoridationists linking water fluoridation with Down’s syndrome, cardiovascular disease, cancer in humans and animals, and other conditions. Controlled fluoridation of community water has been shown to be the most effective public health measure in reducing caries. Anti-fluoridationists have attempted to link water fluoridation with allergies, Down’s syndrome, heart disease, and cancer. There is no evidence that water containing optimal concentrations (0.7–1.2 ppm) of fluoride impairs general health.