
doi: 10.1400/22861
pmid: 11702654
We propose a model for the dynamics of the immune system by considering the subpopulations of virgin and memory T lymphocytes on a time scale corresponding to the human life span. In the deterministic balance equation we introduce a fluctuating term in order to take into account the chronic antigenic stress. Starting from the hypothesis that the depletion of virgin cells with cytotoxic properties (CD8+) is a mortality marker, the model provides survival curves quite similar to the demographic curves.
CD4-Positive T-Lymphocytes, Aging, Cell Death, Cell Survival, T-Lymphocytes, Models, Immunological, Cell Count, Thymus Gland, CD8-Positive T-Lymphocytes, Immune System, Humans, Immunologic Memory, Biomarkers, T-Lymphocytes, Cytotoxic
CD4-Positive T-Lymphocytes, Aging, Cell Death, Cell Survival, T-Lymphocytes, Models, Immunological, Cell Count, Thymus Gland, CD8-Positive T-Lymphocytes, Immune System, Humans, Immunologic Memory, Biomarkers, T-Lymphocytes, Cytotoxic
| selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | 2 | |
| popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network. | Average | |
| influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | Average | |
| impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network. | Average |
