Ten patients with biopsy-proven sarcoidosis with progressive disease were treated with chlorambucil alone or in combination with corticosteroids. Eight of these ten patients showed some degree of improvement which may be attributable to chlorambucil. The responsive patients showed beneficial effects within three months of starting chlorambucil therapy. It is concluded that chlorambucil may be worth a trial in patients with progressive disease unresponsive to corticosteroids or where corticosteroids are contraindicated.