descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 1975 English Publisher:Elsevier BVJournal:Chest, volume 67, pages 490-491 (issn: 0012-3692,

Authors: Robert B. Mann; Timothy H. Self;

doi: 10.1378/chest.67.4.490

pmid: 1122784

Interaction of Rifampin and Warfarin

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Abstract

A 72-year-old man who had been taking rifampin daily for several months was concurrently administered warfarin daily for ten weeks. During this period, the prothrombin time (PT) rose remarkably little as the dosage of warfarin was increased. With difficulty, satisfactory anticoagulation was achieved by giving warfarin 20 mg daily. On discontinuation of rifampin therapy, the PT increased significantly, and subsequent stabilization of the PT within therapeutic range required treatment with warfarin 7.5 mg daily.

Related Organizations

University of Tennessee System
United States
University of Tennessee Health Science Center
United States

Keywords

Male, Prothrombin Time, Humans, Drug Interactions, Warfarin, Rifampin, Aged

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