s: To compare the relative usefulness of the different indexes derived from pulse oximetry in the diagnosis of obstructive sleep apnea (OSA), and to determine if a combination of these indexes improves the prediction of the apnea-hypopnea index (AHI) measured by polysomnography.Prediction model developed from 224 patients, validated prospectively in 101 patients from the same center (group 1) and in 191 patients from a different sleep center (group 2).Two independent sleep clinics run by university sleep specialists.Patients who underwent polysomnography for suspicion of OSA.The following indexes were calculated from pulse oximetry recordings performed simultaneously during polysomnography: (1) Delta index, the average of the absolute differences of oxygen saturation between successive 12-s intervals; (2) desaturation events per hour to 2%, 3%, and 4% levels; and (3) cumulative time spent below 90%, 88%, 86%, 84%, 82%, and 80% saturation.The best predictor was the Delta index, although desaturation events provided similar levels of diagnostic accuracy. An aggregation of multivariate models using combination of indexes reduced the prediction error (r(2) = 0.70) significantly (p or = 30/h) disease, respectively.The Delta index and oxygen desaturation indexes provided similar levels of diagnostic accuracy. The combination of indexes improved the precision of the predicted AHI and may offer a potentially simpler alternative to polysomnography.