The effect of apolipoprotein(a)-, apolipoprotein E-, and apolipoprotein A4- polymorphisms on quantitative lipoprotein(a) concentrations
Copyright policy )The effect of apolipoprotein(a)-, apolipoprotein E-, and apolipoprotein A4- polymorphisms on quantitative lipoprotein(a) concentrations
AbstractThe effects of apolipoprotein (a), apolipoprotein-E, and apolipoprotein-A4 isoforms on quantitative lipoprotein(a) [Lp(a)] levels were assessed in a sample of 142 Dutch families consisting of two parents and their adolescent twin offspring. A total heritability of 95% was estimated for plasma Lp(a) concentrations. The largest part of this heritability was due to the apo(a) locus which explained 61% of the total variance in Lp(a) levels. The pattern of familial correlations for the residual part of the Lp(a) variance that could not be attributed to the apo(a) isoforms, suggested genetic influences on the residual variance. We addressed the question whether this residual genetic variance could be ascribed to the apoE or the apoA4 locus. A simultaneous analysis of all three loci showed that both the apoE and the apoA4 polymorphism did not contribute significantly to Lp(a) variation. Twin Research (2000) 3, 152–158.
- Vrije Universiteit Amsterdam Netherlands
- Vrije Universiteit Brussel Belgium
- University of Queensland Australia
- Faculty of Behavioural and Movement Sciences, Biological Psychology Netherlands
- QIMR Berghofer Medical Research Institute Australia
321011 Medical Genetics, Netherlands Twin Register (NTR), Parents, 730106 Cardiovascular system and diseases, Adolescent, Apo(a), heritability, familial resemblance, Antioxidants, Genetic Heterogeneity, C1, Apolipoproteins E, 616, Twins, Dizygotic, Humans, Protein Isoforms, ApoA4, Apolipoproteins A, Netherlands, Likelihood Functions, Chi-Square Distribution, Polymorphism, Genetic, Chromosome Mapping, Genetic Variation, twins, Twins, Monozygotic, Middle Aged, parent–offspring, lipoprotein(a) [Lp(a)] concentrations, parent-offspring, Algorithms, ApoE, Lipoprotein(a)
321011 Medical Genetics, Netherlands Twin Register (NTR), Parents, 730106 Cardiovascular system and diseases, Adolescent, Apo(a), heritability, familial resemblance, Antioxidants, Genetic Heterogeneity, C1, Apolipoproteins E, 616, Twins, Dizygotic, Humans, Protein Isoforms, ApoA4, Apolipoproteins A, Netherlands, Likelihood Functions, Chi-Square Distribution, Polymorphism, Genetic, Chromosome Mapping, Genetic Variation, twins, Twins, Monozygotic, Middle Aged, parent–offspring, lipoprotein(a) [Lp(a)] concentrations, parent-offspring, Algorithms, ApoE, Lipoprotein(a)
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