Noncanonical Inflammasomes: Caspase-11 Activation and Effector Mechanisms
Copyright policy )Noncanonical Inflammasomes: Caspase-11 Activation and Effector Mechanisms
Inflammasomes are cytosolic, multiprotein complexes assembled by members of the NOD-like receptor (NLR) and PYHIN protein families in response to pathogen-associated molecular patterns (PAMPs) and danger signals, and serve as activation platforms for caspase-1. Recently, a new noncanonical inflammasome pathway has been described that activates caspase-11, an understudied pro-inflammatory caspase. Despite new insights into the signaling events that control caspase-11 activation, a number of unanswered questions remain...
- University of Basel Switzerland
- Stanford University United States
Mice, Knockout, QH301-705.5, Inflammasomes, Macrophages, RC581-607, Pearls, Caspases, Initiator, Enzyme Activation, Mice, Caspases, Phagosomes, Gram-Negative Bacteria, NLR Family, Pyrin Domain-Containing 3 Protein, Animals, Immunologic diseases. Allergy, Biology (General), Carrier Proteins, Signal Transduction
Mice, Knockout, QH301-705.5, Inflammasomes, Macrophages, RC581-607, Pearls, Caspases, Initiator, Enzyme Activation, Mice, Caspases, Phagosomes, Gram-Negative Bacteria, NLR Family, Pyrin Domain-Containing 3 Protein, Animals, Immunologic diseases. Allergy, Biology (General), Carrier Proteins, Signal Transduction
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