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https://dx.doi.org/10.1371/jou...
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RNA modification of an RNA modifier prevents self-RNA sensing

descriptionPublicationkeyboard_double_arrow_right Article 30 Jul 2021 English Publisher:Public Library of Science (PLoS)Journal:PLOS Biology, volume 19, page e3001342 (eissn: 1545-7885, Copyright policy )
Authors: Daltry L. Snider; Stacy M. Horner;

doi: 10.1371/journal.pbio.3001342

pmid: 34329302

pmc: PMC8323910

RNA modification of an RNA modifier prevents self-RNA sensing

Abstract

A new study in PLOS Biology finds that interferon (IFN)-induced adenosine deaminase acting on RNA 1 (ADAR1) mRNA is N6-methyladenosine (m6A) modified to promote its translation, enabling ADAR1 to modify self-double-stranded RNAs (dsRNAs) generated during the IFN response and preventing activation of the melanoma differentiation-associated protein 5 (MDA5)-mediated host antiviral response.

Related Organizations
Keywords

Adenosine, QH301-705.5, Adenosine Deaminase, RNA-Binding Proteins, Interferons, Biology (General), Primer, RNA, Double-Stranded

  • BIP!
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    selected citations
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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 2
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Average
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
2
Average
Average
Average
Green
gold