The Circadian Clock Coordinates Ribosome Biogenesis
Copyright policy )The Circadian Clock Coordinates Ribosome Biogenesis
Biological rhythms play a fundamental role in the physiology and behavior of most living organisms. Rhythmic circadian expression of clock-controlled genes is orchestrated by a molecular clock that relies on interconnected negative feedback loops of transcription regulators. Here we show that the circadian clock exerts its function also through the regulation of mRNA translation. Namely, the circadian clock influences the temporal translation of a subset of mRNAs involved in ribosome biogenesis by controlling the transcription of translation initiation factors as well as the clock-dependent rhythmic activation of signaling pathways involved in their regulation. Moreover, the circadian oscillator directly regulates the transcription of ribosomal protein mRNAs and ribosomal RNAs. Thus the circadian clock exerts a major role in coordinating transcription and translation steps underlying ribosome biogenesis.
- École Polytechnique Fédérale de Lausanne EPFL Switzerland
- University of Lausanne Switzerland
- University of Queensland Australia
- University of Queensland Australia
- Nestlé (France) France
2800 Neuroscience, 571, 1300 Biochemistry, Signaling Pathway, QH301-705.5, Gene-Expression, Genetics and Molecular Biology, Mechanistic Target of Rapamycin Complex 1, Protein S6 Kinase, 1100 Agricultural and Biological Sciences, Mice, Eukaryotic Translation, 1300 Biochemistry, Genetics and Molecular Biology, Circadian Clocks, Messenger-Rna Translation, Saccharomyces-Cerevisiae, Animals, RNA, Messenger, Biology (General), Eukaryotic Initiation Factors, Extracellular Signal-Regulated MAP Kinases, Mice, Knockout, TOR Serine-Threonine Kinases, 2400 Immunology and Microbiology, Extends Life-Span, ARNTL Transcription Factors, Cell-Growth, Circadian Rhythm, Cryptochromes, Enzyme Activation, Mice, Inbred C57BL, Gene Expression Regulation, RNA, Ribosomal, Multiprotein Complexes, Protein Biosynthesis, Transcriptional Activity, Caenorhabditis-Elegans, Pol1 Transcription Initiation Complex Proteins, Proto-Oncogene Proteins c-akt, Ribosomes, Signal Transduction, Research Article
2800 Neuroscience, 571, 1300 Biochemistry, Signaling Pathway, QH301-705.5, Gene-Expression, Genetics and Molecular Biology, Mechanistic Target of Rapamycin Complex 1, Protein S6 Kinase, 1100 Agricultural and Biological Sciences, Mice, Eukaryotic Translation, 1300 Biochemistry, Genetics and Molecular Biology, Circadian Clocks, Messenger-Rna Translation, Saccharomyces-Cerevisiae, Animals, RNA, Messenger, Biology (General), Eukaryotic Initiation Factors, Extracellular Signal-Regulated MAP Kinases, Mice, Knockout, TOR Serine-Threonine Kinases, 2400 Immunology and Microbiology, Extends Life-Span, ARNTL Transcription Factors, Cell-Growth, Circadian Rhythm, Cryptochromes, Enzyme Activation, Mice, Inbred C57BL, Gene Expression Regulation, RNA, Ribosomal, Multiprotein Complexes, Protein Biosynthesis, Transcriptional Activity, Caenorhabditis-Elegans, Pol1 Transcription Initiation Complex Proteins, Proto-Oncogene Proteins c-akt, Ribosomes, Signal Transduction, Research Article
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