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Reassortment Patterns in Swine Influenza Viruses

Authors: Hossein Khiabanian; Vladimir Trifonov; Raul Rabadan;

Reassortment Patterns in Swine Influenza Viruses

Abstract

Previous human influenza pandemics were the results of emerging viruses from non-human reservoirs, with at least two caused by strains of mixed human and avian origin. Also, many cases of swine influenza viruses have reportedly infected humans, including the recent human H1N1 strain, isolated in Mexico and the United States. Pigs are documented to get infected with human, avian, and swine viruses and allow productive replication, thus it has been conjectured that they are the "mixing vessel" that create reassortant strains, causing the human pandemics. In this paper, we apply several statistical techniques to an ensemble of publicly available swine viruses to study the reassortment phenomena. The reassortment patterns in swine viruses confirm previous results found in human viruses that the glycoprotein coding segments reassort most often. Moreover, one of the polymerase segments (PB1), reassorted in the strains responsible for the last two human pandemics of 1957 and 1968, also reassorts frequently.

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Keywords

Membrane Glycoproteins, Models, Statistical, Genes, Viral, Geography, Swine, Science, Q, R, Genome, Viral, Orthomyxoviridae, Birds, Influenza A Virus, H1N1 Subtype, Species Specificity, Medicine, Animals, Humans, Codon, Reassortant Viruses, Research Article

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    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
57
Top 10%
Top 10%
Top 10%
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gold
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