As a computing accelerator, a large-scale photonic spatial Ising machine has great advantages and potential due to its excellent scalability and compactness. However, the current fundamental limitation of a photonic spatial Ising machine is the configuration flexibility for problem implementation in the accelerator model. Arbitrary spin interactions are highly desired for solving various non-deterministic polynomial (NP)-hard problems. In this paper, we propose a novel quadrature photonic spatial Ising machine to break through the limitation of the photonic Ising accelerator by synchronous phase manipulation in two sections. The max-cut problem solution with a graph order of 100 and density from 0.5 to 1 is experimentally demonstrated after almost 100 iterations. Our work suggests flexible problem solving by the large-scale photonic spatial Ising machine.