Fundamental and applied studies on ICP-MS conducted by the scientists in Mainland China in recent 10 years were briefly reviewed. Creative researches on novel sample introduction technique and ICP-MS based bioanalysis have been performed, playing a leading role in respective fields, and those in the fields of elemental speciation and metallomics are impressive. Instrumentation of new units/devices still needs to be strengthened, and close attentions should be paid on ICP-MS applications to real-world biological systems. Studies of imaging of elements and corresponding element-tagged molecules in inorganic and biological samples using ICP-MS is waiting for further developed.