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Synthetic Genomics and the Construction of a Synthetic Bacterial Cell

Authors: John I, Glass;

Synthetic Genomics and the Construction of a Synthetic Bacterial Cell

Abstract

The first synthetic cellular organism was created in 2010 and based on a very small, very simple bacterium called Mycoplasma mycoides . The bacterium was called synthetic because its DNA genome was chemically synthesized rather than replicated from an existing template DNA, as occurs in all other known cellular life on Earth. The experiment was undertaken in order to develop a system that would allow creation of a minimal bacterial cell that could lead to a better understand of the first principles of cellular life. The effort resulted in new synthetic genomics techniques called genome assembly and genome transplantation. The ability of scientists to design and build bacteria opens new possibilities for creating microbes to solve human problems.

Related Organizations
Keywords

DNA, Bacterial, Biomedical Research, Genotype, Systems Biology, Mycoplasma mycoides, Gene Expression Regulation, Bacterial, Models, Biological, Phenotype, Animals, Humans, Synthetic Biology, Molecular Biology, Genome, Bacterial

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    popularity
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    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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Powered by OpenAIRE graph
Found an issue? Give us feedback
selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
13
Top 10%
Average
Average
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