Therapeutic Drug Monitoring of Lamotrigine

descriptionPublicationkeyboard_double_arrow_right Article 01 May 2002 English Publisher:SAGE PublicationsJournal:Annals of Pharmacotherapy, volume 36, pages 917-920 (issn: 1060-0280, eissn: 1542-6270,

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Authors: Elaine, Chong; L Lee, Dupuis;

doi: 10.1345/aph.1a252 , 10.1345/1542-6270(2002)036<0917:tdmol>2.0.co;2

pmid: 11978172

Therapeutic Drug Monitoring of Lamotrigine

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Abstract

OBJECTIVE: To evaluate the usefulness of routine monitoring of serum lamotrigine concentration. DATA SOURCE: Literature was accessed through MEDLINE (1990–January 2001). Key search terms included lamotrigine, pharmacokinetics, and epilepsy. DATA SYNTHESIS: A decision-making algorithm was used to evaluate the clinical evidence to support or refute the routine use of serum lamotrigine concentrations to adjust doses. The value of serum lamotrigine concentration monitoring remains controversial, primarily because clear relationships between concentration and pharmacologic response (either efficacy or toxicity) have not been demonstrated. CONCLUSIONS: Serum concentration monitoring of lamotrigine is not recommended as a tool for routine dose adjustment.

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Keywords

Clinical Trials as Topic, Epilepsy, Triazines, MEDLINE, Biological Availability, Lamotrigine, Review Literature as Topic, Treatment Outcome, Humans, Anticonvulsants, Drug Monitoring, Retrospective Studies

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