descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Jan 2013Publisher:Avens Publishing GroupJournal:Journal of Syndromes, volume 1 (eissn: 2380-6036,

Authors: Runhua Liu; Lizhong Wang; Wei-Hsiung Yang; Silin Li;

doi: 10.13188/2380-6036.1000001

pmid: 25844400

pmc: PMC4383293

IPEX Syndrome, FOXP3 and Cancer

- Summary
- Metrics

Abstract

In this review, we introduce the IPEX syndrome and its relationship with germline mutations of the FOXP3 gene. We then describe the multiple functional roles of FOXP3 in regulatory T cells and epithelial cells as well as in IPEX syndrome and tumor progression. Potential mechanisms of FOXP3 inactivation and transcriptional regulation are discussed with recent advances. Finally, we point out current issues and a potential FOXP3-mediated therapeutic strategy as well as the reactivation of FOXP3 in patients with IPEX syndrome and cancer.

Related Organizations

Mercy College
United States
Mercer University Health Sciences Center
United States
University of Alabama at Birmingham
United States

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	4
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average