ABSTRACT: The objective of this work is to formulate Nanoplex formulation which enhances the drug solubility and also to enhance the dissolution rate of the formulation which were prepared. Complex nanoplex is formed when positively or negatively charged molecules of the drug react with oppositely charged polyelectrolyte. In this study, we use hydrochlorothiazide as a study drug and dextran sulphate as anionic polyelectrolyte. During the procedure crystalline nanoplex is formed due to electrostatic interactions between API and polyelecrolyte. The nanoplex shaped by this method upgrades dissolvability and disintegration rate of inadequately water solvent medication. It was assessed for complexation effectiveness, % yield, molecule size, zeta potential, SEM, TEM, XRD, soaked solvency study and so forth. This gives particles having molecule size in the scope of 100-200nm.Amongst different ratio, 1:1 showed highest Complexation efficiency as 96.3%, % yield and drug loading as 82 % and 77.69 % respectively. Solubility and stability of hydrochlorothiazide, poorly water-soluble molecule can be increased with formulation of hydrochlorothiazide nanoplex.